ParkinsonCanadaV1, Main, Exploration, bibRecord, 002077

NSAID Use and the Risk of Parkinson's Disease: Systematic Review and Meta-Analysis of Observational Studies

Identifieur interne : 002077 ( Main/Exploration ); précédent : 002076; suivant : 002078

NSAID Use and the Risk of Parkinson's Disease: Systematic Review and Meta-Analysis of Observational Studies

Auteurs : Ali Samii [États-Unis] ; Mahyar Etminan [Canada] ; Matthew O. Wiens [Canada] ; Siavash Jafari [Canada]

Source :

Drugs & aging [ 1170-229X ] ; 2009.

RBID : Pascal:09-0427296

Descripteurs français

Pascal (Inist)
- Antiinflammatoire non stéroïde, Facteur risque, Maladie de Parkinson, Revue systématique, Article synthèse, Métaanalyse, Personne âgée, Ibuprofène, Acide acétylsalicylique, Analgésique, Antipyrétique, Inhibiteur thromboagrégation, Risque relatif.
Wicri :
- topic : Personne âgée.

English descriptors

KwdEn :
- Acetylsalicylic acid, Analgesic, Antiplatelet agent, Antipyretic, Elderly, Ibuprofen, Metaanalysis, Non steroidal antiinflammatory agent, Parkinson disease, Relative risk, Review, Risk factor, Systematic review.

Abstract

Background: Several studies have suggested that NSAID use may modify the risk of developing Parkinson's disease (PD). Objective: Our aim was to conduct a meta-analysis of observational studies evaluating NSAID use and the risk of PD. Methods: We systematically searched MEDLINE (1966-November 2008), EMBASE (1980-November 2008) and other databases. Data from 11 studies were included in the meta-analysis. We used the random effects model to calculate risk ratios (relative risks) and their corresponding 95% confidence intervals (CIs). Results: The pooled risk ratio of PD with NSAID use was 0.95 (95% CI 0.80, 1.12). The pooled risk ratio of PD with high-dose or long-duration NSAID use was 0.91 (95% CI 0.78, 1.05). The pooled risk ratio of PD for aspirin (acetylsalicylic acid) users was 1.08 (95% CI 0.93, 1.26). The pooled risk ratio of PD among ibuprofen users was 0.76 (95% CI 0.65, 0.89). The pooled risk ratio of PD in men using NSAIDs was 0.79 (95% CI 0.69, 0.92), and in women using NSAIDs, it was 0.72 (95% CI 0.45, 1.15). Conclusions: NSAIDs as a class do not seem to modify the risk of PD. However, ibuprofen may have a slight protective effect in lowering the risk of PD. Although the risk ratios of PD in male and female NSAID users were similar, the 95% CI for men was suggestive of a slight risk reduction.

Affiliations:

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 000511
to stream PascalFrancis, to step Curation: 000781
to stream PascalFrancis, to step Checkpoint: 000431
to stream Main, to step Merge: 002235
to stream Main, to step Curation: 002077

Le document en format XML

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<front><div type="abstract" xml:lang="en">Background: Several studies have suggested that NSAID use may modify the risk of developing Parkinson's disease (PD). Objective: Our aim was to conduct a meta-analysis of observational studies evaluating NSAID use and the risk of PD. Methods: We systematically searched MEDLINE (1966-November 2008), EMBASE (1980-November 2008) and other databases. Data from 11 studies were included in the meta-analysis. We used the random effects model to calculate risk ratios (relative risks) and their corresponding 95% confidence intervals (CIs). Results: The pooled risk ratio of PD with NSAID use was 0.95 (95% CI 0.80, 1.12). The pooled risk ratio of PD with high-dose or long-duration NSAID use was 0.91 (95% CI 0.78, 1.05). The pooled risk ratio of PD for aspirin (acetylsalicylic acid) users was 1.08 (95% CI 0.93, 1.26). The pooled risk ratio of PD among ibuprofen users was 0.76 (95% CI 0.65, 0.89). The pooled risk ratio of PD in men using NSAIDs was 0.79 (95% CI 0.69, 0.92), and in women using NSAIDs, it was 0.72 (95% CI 0.45, 1.15). Conclusions: NSAIDs as a class do not seem to modify the risk of PD. However, ibuprofen may have a slight protective effect in lowering the risk of PD. Although the risk ratios of PD in male and female NSAID users were similar, the 95% CI for men was suggestive of a slight risk reduction.</div>
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	La maladie de Parkinson au Canada (serveur d'exploration)
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La maladie de Parkinson au Canada (serveur d'exploration)

NSAID Use and the Risk of Parkinson's Disease: Systematic Review and Meta-Analysis of Observational Studies

NSAID Use and the Risk of Parkinson's Disease: Systematic Review and Meta-Analysis of Observational Studies

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri